Are Cannabis or Cannabinoids helpful and effective treatment for cancer?

Photo by Shutterstock

Cancer is a broad term used to describe a wide range of related diseases that are characterized by an abnormal, unregulated division of cells; it is a biological disorder that often results in tumor growth (). Cancer is among the leading causes of mortality in the United States, and by the close of 2016 there will be an estimated 1.7 million new cancer diagnoses (). Relevant to the committee's interest, there is evidence to suggest that cannabinoids (and the endocannabinoid system more generally) may play a role in the cancer regulation processes (). Therefore, there is interest in determining the efficacy of cannabis or cannabinoids for the treatment of cancer.

Using the committee's search strategy only one recent review was found to be of good to fair quality (). The review focused exclusively on the anti-tumor effects of cannabinoids on gliomas. Of the 2,260 studies identified through December 2012, 35 studies met the inclusion criteria. With the exception of a small clinical trial, these studies were all preclinical studies. All 16 of the in vivo studies found an antitumor effect of cannabinoids.

CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING
Nausea and vomiting are common side effects of many cytotoxic chemotherapy agents. A number of pharmaceutical interventions in various drug classes have been approved for the treatment of chemotherapy-induced nausea and vomiting. Among the cannabinoid medications, nabilone and dronabinol were initially approved in 1985 for nausea and vomiting associated with cancer chemotherapy in patients who failed to respond adequately to conventional antiemetic treatments (Todaro, 2012, pp. 488, 490).

 summarized 28 trials reporting on nausea and vomiting due to chemotherapy, most published before 1984, involving 1,772 participants. The cannabinoid therapies investigated in these trials included nabilone (14), tetrahydrocannabinol (6), levonantradol (4), dronabinol (3), and nabiximols (1). Eight studies were placebo controlled, and 20 included active comparators (prochlorperazine 15; chlorpromazine 2; dromperidone 2; and alizapride, hydroxyzine, metoclopramide, and ondansetron 1 each). Two studies evaluated combinations of dronabinol with prochlorperazine or ondansetron. The average number of patients showing a complete nausea and vomiting response was greater with cannabinoids than the placebo (OR, 3.82, 95% CI = 1.55–9.42) in 3 trials of dronabinol and nabiximols that were considered low-quality evidence.  concluded that all trials suggested a greater benefit for cannabinoids than for both active agents and for the placebo, although these did not reach statistical significance in all trials.

DELTA 8 STORE - SOURCE FOR QUALITY PRODUCTS

The legal hemp compound will boost your mood, make you giddy, and won't put you to sleep or leave you with a hangover. When you choose delta 8 products, you get a euphoric feeling that surpasses CBD but doesn't hit the heights of THC. Buy delta 8 THC at the Delta 8 Store and add pre-rolls, oils, vape cartridges, and edibles to your online shopping cart today! With fast, discreet shipping, you'll receive high-quality, third-party tested THC-lite products to use on your weekend while you get tasks done around the house or with friends while enjoying summertime and fall activities.