Linking endocannabinoids and exercise could lead to better treatment for depression

Exercise to improve the mood. Photo by Shutterstock

We all know that exercise improves mood for people, even those with depression, but there are still questions about exactly how it makes people feel better.

The answers may be found in the endocannabinoid system. The system is made up of the body's own naturally occurring cannabinoid molecules and their receptors, said Jacob Meyer, an assistant professor of kinesiology at Iowa State University. Activation of these receptors appears to strengthen connections in the brain and may influence pain and depression.

In a new study, Meyer and researchers at the University of Wisconsin-Madison, Medical College of Wisconsin and William S. Middleton Memorial Veterans Hospital, measured endocannabinoid levels and changes in mood before and after exercise sessions with varying levels of intensity. They found a significant boost in endocannabinoids and improvements in mood following prescribed moderate-intensity exercise.

The findings are published in Medicine & Science in Sports & Exercise. Meyer says understanding the link between endocannabinoid levels, mood and exercise could lead to better treatment options.

Preferred vs. prescribed exercise

The researchers analyzed data from 17 women with depression. Each woman completed two, 30-minute exercise sessions on a stationary bike – one at a prescribed moderate intensity and a second of the participants' own preferred intensity. Both sessions improved mood, but the researchers only noted an increase in endocannabinoid levels for moderate intensity exercise. There was no difference for preferred intensity.

Meyer says this was surprising, but the differences may stem from variation in the preferred session. For example, some women stayed consistently at a lighter intensity, while others completed intervals. With a small sample, the variation may have obscured the relationship between the preferred intensity and change in endocannabinoids, Meyer said.

The findings are consistent with a 2016 study, in which Meyer and his colleagues looked at the effect of exercise on brain-derived neurotrophic factor or BDNF, a protein that regulates neuron growth and survival. People with depression typically have lower levels of BDNF. The 2016 study found that when women with depression were prescribed an exercise session similar in intensity to one they selected, their BDNF levels were significantly higher following the prescribed session.

"Having someone else prescribe the exercise could be involved in both the psychological and biological response to exercise," Meyer said.

Effects appear to be long-lasting

For each exercise session, researchers collected blood samples immediately after exercise and also measured mood and anxiety at 10 minutes and 30 minutes post-workout. Changes in endocannabinoids were significantly related to the improvement in mood up to 30 minutes after the moderate exercise, suggesting that the system contributes to the mood-enhancing effects of prescribed exercise, Meyer said.

"These results show us that the effect of prescribed moderate-intensity exercise on mood is generally pretty quick and lasts for a while at a relatively sustained rate," Meyer said. "However, given that people felt better after the preferred exercise session, even though it didn't change endocannabinoid levels, multiple factors are likely involved in how exercise makes people feel better."

 

What is endocannabinoid system

The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors (CBRs), and cannabinoid receptor proteins that are expressed throughout the vertebrate central nervous system (including the brain) and peripheral nervous system.The endocannabinoid system remains under preliminary research, but may be involved in regulating physiological and cognitive processes, including fertility, pregnancy, pre- and postnatal development, various activity of immune system, appetite, pain-sensation, mood, and memory, and in mediating the pharmacological effects of cannabis. The ECS plays an important role in multiple aspects of neural functions, including the control of movement and motor coordination, learning and memory, emotion and motivation, addictive-like behavior, and pain modulation, among others.

 

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Source:

Iowa State University