Research: Delta 8 THC increase food consumption and alter neurotransmitter levels following weight loss

 

We know that body sizes are not all the same and that every single human being looks unique. Every body has a different needs. Body size and structure is determined and influenced by a variety of forces, which is why all individuals look different and when it gets to finding the perfect way to lose weight that employ healthy eating, potentially lower carbs, we all can agree on few things that we need to follow:

  • reduce appetite
  • improve your metabolic health
  • rest well

 

Few recent studies came to a conclusion that Delta 8 THC could help with reducing the weight but still maintain a healthy eating habit.
Few researches provided the data that the effect of 0.001 mg/kg delta(8)-tetrahydrocannabinol (THC) on food consumption, cognitive function, and neurotransmitters in mice. Sabra mice were treated with vehicle, THC, or THC+CB1 antagonist (SR141716A). The mice were fed for 2.5 h a day for 9 or 50 days. In the 9-day schedule, THC-treated mice showed a 16% increase in food intake compared with controls (P<.001). This effect was reversed by the antagonist (P<.01). In the long-term schedule a 22% increase in intake (P<.05) was recorded. During the course of the 9- and 50-day experimental protocol, all mice lost about 20% and 10% of their original weight, respectively, to reach approximately the same weights, which were not significantly different between the different treatment groups. In addition, THC caused an increase in activity (P<.05). Cognitive function showed a tendency to improve (P<.06) in the THC-treated mice, which was reversed by the antagonist for Days 4 and 5 of the maze (P<.01, and P<.05, respectively). Significant decreases in dopamine and serotonin (5-HT) levels were found both in the hypothalamus (P<.01) and the hippocampus (P<.01, P<.05), respectively, while norepinephrine (NE) levels showed tendency to increase in both the hypothalamus and hippocampus. Delta(8)-THC increased food intake significantly more (P<.05) than did delta(9)-THC, while performance and activity were similar. Thus, delta(8)-THC (0.001 mg/kg) caused increased food consumption and tendency to improve cognitive function, without cannabimimetic side effects. Hence, a low dose of THC might be a potential therapeutic agent in the treatment of weight disorders.

 

By Yosefa Avraham, Dikla Ben-Shushan, Aviva Breuer, Olga Zolotarev, Avital Okon, Nir Fink, Vered Katz, Elliot M Berry

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